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SoftGenetics
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Image Search Results
Journal: Frontiers in Reproductive Health
Article Title: Hyperhomocysteinemia in hypofertile male patients can be alleviated by supplementation with 5MTHF associated with one carbon cycle support
doi: 10.3389/frph.2023.1229997
Figure Lengend Snippet: The one carbon and the folate cycles; indicating the MTHFR bottleneck and the two severe Michaelis and Menten effects induced by folic acid (FA) at high doses when excessive unmetabolized metabolite is present upstream from MTHFR: at the level of DHFR (DiHydrofolate reductase) [Bailey and Ayling , and at the level of MTHFR itself]. A further negative effect occurs due to saturation of the solute carrier for the natural folate 5MTHF by UMFA (UnMetabolized folic acid).
Article Snippet: Tests are carried out on 5 μl venous blood samples, using the
Techniques: